https://www.jasonyilab.org/our-team daily 0.75 2025-09-21 https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1526615901764-GBAB60OTRPY23O4IHQL6/76366_675358239524_8032406_n.jpg Our Team https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/756e99bb-7458-481e-9490-832d9d9198cd/Gunelson.jpeg Our Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1519773569021-1Q5SBUVGVYJ4ERB0NU5S/image.png Our Team https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1558411095750-ZCPXMF5SJGU5QUPOHWO6/lab%2Bphoto%2B2.jpg Our Team https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/8b110647-d81a-4060-ac7b-93446e057f2f/Image+from+iOS+%285%29.jpg Our Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1526582508580-RD8SWUH6YLA4R39ZOX5T/image001.jpg Our Team https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1538063820406-QNCIW7RQLGWS0MV486HM/image-asset.jpeg Our Team https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/7dd0d4e8-596c-47b9-a34d-af2cd0ef8e1d/Marissa.jpeg Our Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1626845079347-CKSOSRRDB9EVRMNBOF5U/D877F5DB-CB79-49FB-A261-B8DF426BBB4C.jpeg Our Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/732bf028-3872-4ba9-bda2-92ec568bf3f9/image+%281%29.png Our Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1618497505316-UX7Q3GP1G3851ISS00M6/16F93999-62E1-420A-9A30-8F70B0BF6867.jpg Our Team https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1502736815426-GRP3QVWBWLAECMG3U9YV/XiaoYiGao.jpg Our Team https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/406343c7-1b87-4426-b693-a4ace19b5697/miko-dai-280x386-1-280x386.jpeg Our Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1503609523482-KHFB91MCI12YF6VHYFXR/Together.jpg Our Team - Future Student/Postdoc https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1570572648016-8BAXB8OYLV2NZ0BRXRB6/file.jpg Our Team https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1538064136447-LS3RG5PA12AX0IXJ28UH/Katie-Lefton.jpg Our Team https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1572298976575-3WIPXYSMQH8J4TKMZUJT/12341328_10208222331902326_8328664210390675095_n.jpg Our Team https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1557761329963-ON2J0GNUW14SQUFQC2LD/Jinghan_Zhao.jpg Our Team https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1509997954717-CMW89ADSX3B807MT3HXR/20171105_103937.jpg Our Team https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1538083137304-Y57AWMP4NUU0LC1662DL/Michelle+Hsiao.jpg Our Team https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1526071959173-Q5UFDWSDY1N8DHUWOXMP/bg_home-20160921.jpg Our Team https://www.jasonyilab.org/publications daily 0.75 2023-07-03 https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1525274089615-BXXR00FHJEYL5B7XY25N/chess.jpg Publications https://www.jasonyilab.org/contact-us daily 0.75 2020-12-13 https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1502760099677-N6PSPZAO77IFW7P67BER/gateway-arch-st-louis-night-john-magyar-photography.jpg Contact Us https://www.jasonyilab.org/living-in-st-louis daily 0.75 2018-05-11 https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1526059030323-HTB7ZA4LRVU12W1OVT9X/pfstl_logo_750.png Living in St. Louis https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1502830317007-C8OF4AQFJEQ2F0VV66XX/538-logo-fivethirtyeight.png Living in St. Louis -   St. Louis is the New Startup Frontier St Louis is the New Startup Frontier https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1502890223506-HVI57S6OWIR4Z9JQ6CLQ/CWE-1440.jpg Living in St. Louis - A Place worth saving: the story of the central west end A great documentary about the role of Washington University and the School of Medicine in the long-term revitalization of the local neighborhood. A Place Worth Saving: The Story of the Central West End https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1502740257612-GQS6PMBOQM3NP1OME6J5/fall_2013-3.jpg Living in St. Louis https://www.jasonyilab.org/news daily 0.75 2024-04-19 https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1525274448114-Q94IX2LNJ7YI5UFHNKHM/city-6.jpg News and Events https://www.jasonyilab.org/home daily 1.0 2017-08-15 https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1502822858041-FNUDYC14SWAH34EAUC30/Neuron.gif Home https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1502745557062-J238U2WAX2UK2XT1ZJBF/pymol.gif Home https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1502728388592-W13DXO0V98UJ591MORGF/hero-visit2.jpg Home https://www.jasonyilab.org/research daily 0.75 2022-07-20 https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1550699217623-QS8DZZN6DU6VJ5IJMLIS/2017_sloan_logo.jpg Research https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1618526366700-HDY6ADG6ON83A6TWPKNC/Hope_Center_Logo.jpeg Research https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1b0133d2-1ad7-4848-b335-157b8bc96bc4/Untitled-1.jpg Research - Make it stand out Crystal structure of the UBE3A HECT domain (silver) in complex with an accessory UBCH7 E2 enzyme. Variants that change UBE3A activity are shown color-coded to visualize clustering in the structure. Positions of gain-of-function variants are indicated. Our work identified a ubiquitin-binding domain (pink) required for polyubiquitin chain formation. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1509998941419-DKBJI9Q5MTMAGF9VN69Q/logo-sfari.png Research https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/f86359bf-8692-40c0-83a5-38f5063cf397/Angelman.png Research - Make it stand out Pedigree showing maternal inheritance of Angelman syndrome. Picture of a 5 year old child with Angelman. Figure from Yokoyama-Rebollar et al., Mol. Cytogenet (2015). https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1512513059730-U11Z9PFDLYPD3E69TDYC/wh_head_4.jpg Research https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/966611be-82a9-4534-9eba-099de6b89629/NatComm+Figure+6_Ed+Rev_v1.jpg Research - Make it stand out Ultrasonic vocalizations, a measurement of early life communication, is perturbed in mice carrying a maternally-inhertied hyperactivating mutation (Top), but not a paternally-inherited mutation (Bottom). Measurements were taken in pups at postnatal day (P) 5, 7, and 9. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1550699201473-ANIQVDBVSW8XSHE8CEN6/hUm30BZ8_400x400.jpg Research https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1509998923085-DQSOOSTDHW2UNVPY3366/Brain_Behavior_Research_Foundation_logo.png Research https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1606808674826-BMHA2PGA3LAKC0PWXFLL/NIH-NIMH-logo-new.png Research https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1502766952965-T8T11RLQME40VRSQEPK3/image-asset.jpeg Research https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/587d1686-06ee-4f42-8f66-9b55447f5b0d/NatComm+Figure+2_Ed+Rev_v1.jpg Research - Make it stand out Functional screening of UBE3A variants showing loss-of-function (blue shading) and gain-of-function (red shading) variants. Gray represents benign variants. Data from Weston et al., Nature Communications, 2021. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1526393648301-SQFXIUGLEW0PYVBOUYDX/Soulard.jpg Research https://www.jasonyilab.org/jasonyi daily 0.75 2020-06-18 https://www.jasonyilab.org/yi-lab-timeline daily 0.75 2024-05-18 https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/ffadb1a0-430e-4bff-a129-f53cd4ae2bd4/126EEF2F-EA1F-471E-870B-FCE0AB9C7718_1_105_c.jpg Yi Lab Timeline - Make it stand out October, 2021 - We organized a departmental donation drive for Afghan refugees arriving in St. Louis https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1630622520026-8KXLXI1AA2Y8Y6BH253U/IMG_8149.jpeg Yi Lab Timeline - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/d42d2b0b-3b44-4df0-9c84-58c5b01e2438/processed-919BB637-67D4-4C36-8E42-8CA76F053D45.jpg Yi Lab Timeline - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1630622682263-8GI943JLFKQWPLU051OX/IMG_8150.jpeg Yi Lab Timeline - Make it stand out August, 2021 - The annual Gabel-Yi-rly summer BBQ and cornhole tournament resumes!! https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1630622416852-QI4OKXRKFW2T4XIQG1MJ/IMG_8147.jpeg Yi Lab Timeline - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1557617126810-LQ8KZOJM0PB06KO5V882/IMG_3122.jpeg Yi Lab Timeline May, 2019 - The lab bids a proud and heartfelt farewell to Renee, who will be moving on to medical school. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/8b0024c8-6f31-434e-9961-d149b3724535/IMG_8814.jpg Yi Lab Timeline - Make it stand out September, 2023 - The lab gets busy packing and moving to the new Neuroscience Research Building! https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/b69d2cf8-a768-4886-912d-57db50018a03/IMG_9333.jpg Yi Lab Timeline - Make it stand out May 2022 - The lab participates in the St. Louis Walk for Angelman Syndrome https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1529809549066-W7ISWA3Q0ZCB8CKXJLH5/fullsizeoutput_3e.jpeg Yi Lab Timeline August, 2017 - Solar eclipse totality! https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1544378833271-Y611MTVVMZZBSYM73MU5/IMG_2442.jpg Yi Lab Timeline December 2018 - 2nd annual Yi-Gabel labs holiday party https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1529809987053-7KMV5KZWCVM5IK3B1JAY/image-asset.jpeg Yi Lab Timeline December, 2017 - Yi lab lunch at U-City Grill https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/6c76443d-ea81-4439-8276-fa8648d3df7f/Image+from+iOS+%284%29.jpg Yi Lab Timeline - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1529810196485-5GK8G750DF6FLP59PL6L/IMG_4181.JPG Yi Lab Timeline April - June, 2018 - The lab in action https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/3b005b13-8f5a-46a8-98c6-9cdace7ccd04/thumbnail_Image.jpeg Yi Lab Timeline - Make it stand out October, 2021 - Kellan’s first (and the lab’s very first) paper is accepted in Nature Communications! https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1529809064628-W8ORZJV9OR9VP9NP6QFA/fullsizeoutput_dab.jpeg Yi Lab Timeline February, 2017 - Lab with a view. Turns out our view of the St. Louis sunsets is amazing. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/e3820cb0-b02d-4a74-a346-d04774f40a72/IMG_9014.jpeg Yi Lab Timeline - Make it stand out March, 2024 - Congratulations to Dr. Kellan Weston on her Ph.D. defense! https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/902b4167-1a41-4437-9b41-20cccc3e1a79/EF411146-2988-453E-9ED7-EB038549DC35_1_105_c.jpeg Yi Lab Timeline - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/6a96c4cf-e2df-4e18-b713-9dc9969a73f3/IMG_9340.jpg Yi Lab Timeline - Make it stand out May, 2024 - St. Louis Angelman Syndrome Foundation Walk https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/64b8b3bc-1d72-4423-b343-5d99016882c5/IMG_0550.jpg Yi Lab Timeline - Make it stand out December, 2022 - The bids a fond farewell to Jalin as she begins her medical school journey https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/023ccb83-556d-4aa6-90a3-eb2c822abec0/IMG_0967.jpg Yi Lab Timeline - Make it stand out May, 2023 - The lab bids farewell to Alejandro as he graduates from WashU and heads off to greener pastures https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/f8282c25-082a-4261-a80b-aa9d17f4de41/thumbnail_Image+2.jpeg Yi Lab Timeline - Make it stand out Lab bubbly selfie https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/90af8c12-cf8f-41e5-a914-6fb063f7805f/IMG_9209.jpg Yi Lab Timeline - Make it stand out April, 2024 - Solar eclipse totality v2.0 https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/4044de68-9a82-465b-ae2f-d1b9bd47bbe9/IMG_7103.JPG Yi Lab Timeline - Make it stand out April, 2022 - Kellan presents at the ASBMB annual conference in Philadelphia, PA https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/0d827be8-1a94-4006-bfa3-d90afe17bb96/processed-803506DD-7DC9-4EC6-ACD0-5279E07AD43E.jpeg Yi Lab Timeline - Make it stand out December, 2023 - The 7th annual O’ come all Yi/Gabel labs holiday party https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1601529656878-8L7U2IBA23CC1R750SUS/Submission+Crop.jpg Yi Lab Timeline September, 2020 - We did it! First paper submission selfie. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1529940178152-A6G6QBZG6MRCS9KFUFIA/Iggles.jpg Yi Lab Timeline February, 2018 - Iggles win! Iggles win! https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1529810309991-VXEDDV10QJA6FSH2ZOOY/IMG_4211.JPG Yi Lab Timeline June, 2018 - Yi lab lunch, Pappy's Smokehouse https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1529808654513-GHL4SYGY42Y2GGW62CQ4/IMG_2782.JPG Yi Lab Timeline February, 2017 - We ran a gel! https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/092c7588-db19-43f0-a9c2-00f2ca5ae7a0/IMG_0537.jpg Yi Lab Timeline - Make it stand out December, 2022 - The 6th annual O’ come all Yi Gabel labs holiday party https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1576436726307-I75DXK3V3V4SJ4D4QY96/fullsizeoutput_1534.jpeg Yi Lab Timeline https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1544378974930-YM4GD190ANK43H9BSS58/image-asset.jpeg Yi Lab Timeline https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1563143711582-NB2OMOUOY114Y2TWIWZ0/IMG_3684.jpg Yi Lab Timeline July, 2019 - The 3rd annual Gabel Yi-rly lab summer BBQ https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/988d70db-3cab-416d-ad5f-5644f209748f/Hurts_Mahomes_Super+Bowl+57+matchup+graphics_0.jpeg Yi Lab Timeline - Make it stand out February, 2023 - A heartbreaker for the Iggles https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/c696d126-8cfc-4ef8-95cb-e72e9d3c0bb1/processed-E8F81BD7-316A-45B7-BB9D-F0DA8C23100E.jpg Yi Lab Timeline - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1529810145988-DVDWG0QMZJRPXJEZ9Y9C/IMG_4083.JPG Yi Lab Timeline https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/3fd9d749-e95e-4f95-9d93-9b4549f5490d/EFB763BD-5285-4C10-AC35-AD2FD3DB9DF3_1_105_c.jpeg Yi Lab Timeline - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1533247629595-FZ0KCR83ZLD0D4WQSQNX/seq2049.jpg Yi Lab Timeline August, 2018 - The lab goes fishing... https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/6fb14302-0e0d-4c1d-b99a-c0da19d17a79/IMG_8816.jpg Yi Lab Timeline - Make it stand out Goodbye Yi Lab v1.0! https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1576436825755-5YT57DZ1R2H6V638JB6X/IMG_5085.jpeg Yi Lab Timeline December 2019 - 3rd annual Yi-Gabel labs holiday party https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/a249a1bf-f3a4-4353-9bd1-9ef1e7d4da6a/Kellan.jpg Yi Lab Timeline - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1618544864943-LLMI1F0NHQ1MLXXXEEDC/Screen+Shot+2021-03-02+at+5.19.29+PM.png Yi Lab Timeline March, 2021 - Quarantine lab photo #2 https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/c1bd226a-5aa5-48e8-8558-a02585361e56/processed-67DC8092-E880-409B-88CF-6BB8C15D6B8D.jpeg Yi Lab Timeline - Make it stand out March, 2023 - Jason meets Swoop at the Dup15q Gala https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1c164986-6523-49da-a2f6-8e0c081f5212/IMG_8674.jpg Yi Lab Timeline - Make it stand out August, 2023 - Shylyn presents at the 2023 ENDURE scholar poster session https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1529809841857-0NH01CFHVT7Q14GZ6FTO/IMG_3705.JPG Yi Lab Timeline December, 2017 - Inaugural Yi-Gabel labs holiday party https://images.squarespace-cdn.com/content/v1/5991d023f14aa1aa7e957645/1607905185922-9MFHB93TN9S6K1G37WN8/image-asset.png Yi Lab Timeline December, 2020 - The 4th annual Yi-Gabel labs holiday party was a little different this year, but nonetheless highly enjoyable. 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